Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 4 September 1981:
Vol. 213. no. 4512, pp. 1120 - 1122
DOI: 10.1126/science.6267695
Prev | Table of Contents | Next

Articles

Science, Vol 213, Issue 4512, 1120-1122
Copyright © 1981 by American Association for the Advancement of Science

articles

Growth inhibition by adenosine 3',5-monophosphate derivatives does not require 3',5' phosphodiester linkage

TF Martin and JA Kowalchyk

Analogs of adenosine 3',5'-monophosphate (cyclic AMP) inhibit the growth of cultured cell lines. The effects of 8-bromo- and N6-butyryl-substituted analogs of cyclic and noncyclic AMP on six cell lines were examined and were equally inhibitory. Variant cell lines with altered cyclic AMP-dependent protein kinase were more resistant to both cyclic and noncyclic nucleotides. We conclude that growth inhibition by analogs of cyclic AMP (i) does not require a 3',5' phosphodiester bond and (ii) may be mediated by a pathway involving endogenous cyclic AMP.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Global Profiles of Gene Expression Induced by Adrenocorticotropin in Y1 Mouse Adrenal Cells.
B. P. Schimmer, M. Cordova, H. Cheng, A. Tsao, A. B. Goryachev, A. D. Schimmer, and Q. Morris (2006)
Endocrinology 147, 2357-2367
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)