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Science 28 August 1981:
Vol. 213. no. 4511, pp. 1034 - 1036
DOI: 10.1126/science.7268407
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Articles

Science, Vol 213, Issue 4511, 1034-1036
Copyright © 1981 by American Association for the Advancement of Science

articles

Hyperthermia-induced seizures in the rat pup: a model for febrile convulsions in children

D Holtzman, K Obana, and J Olson

Seizures were produced in rat pups by ambient hyperthermia. Seizure threshold temperatures, measured rectally and intracerebrally, increased between 2 and 10 days of age. Electrocortical paroxysmal discharges were confirmed in hyperthermic 6- and 10-day-old pups. The increasing resistance to hyperthermic seizures with maturation and the electroencephalographic changes induced by hyperthermia are similar to those in young children.


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Toxicol Pathol 35, 984-999
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GABA: A Pioneer Transmitter That Excites Immature Neurons and Generates Primitive Oscillations.
Y. Ben-Ari, J.-L. Gaiarsa, R. Tyzio, and R. Khazipov (2007)
Physiol Rev 87, 1215-1284
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Febrile Seizures.
S. Shinnar and T. A. Glauser (2002)
J Child Neurol 17, S44-S52
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