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Science 28 August 1981:
Vol. 213. no. 4511, pp. 1021 - 1022
DOI: 10.1126/science.7022652
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Articles

Science, Vol 213, Issue 4511, 1021-1022
Copyright © 1981 by American Association for the Advancement of Science

articles

In vitro cultivation of the exoerythrocytic stage of Plasmodium berghei from sporozoites

MR Hollingdale, JL Leef, M McCullough, and RL Beaudoin

When inoculated with sporozoites of Plasmodium berghei, the human embryonic lung cell line WI38 supports the complete asexual developmental cycle of the exoerythrocytic stage. Cultured parasites were sensitive to primaquine, were shown to resemble parasites in living hosts by immunofluorescent antibody tests, and on subinoculation into mice induced a red blood cell infection, the gametocytes of which produced sporozoites in anopheline mosquitoes.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
ESTABLISHMENT OF A HUMAN HEPATOCYTE LINE THAT SUPPORTS IN VITRO DEVELOPMENT OF THE EXO-ERYTHROCYTIC STAGES OF THE MALARIA PARASITES PLASMODIUM FALCIPARUM AND P. VIVAX..
J. SATTABONGKOT, N. YIMAMNUAYCHOKE, S. LEELAUDOMLIPI, M. RASAMEESORAJ, R. JENWITHISUK, R. E. COLEMAN, R. UDOMSANGPETCH, L. CUI, and T. G. BREWER (2006)
Am J Trop Med Hyg 74, 708-715
   Abstract »    Full Text »    PDF »
Cultivation of Plasmodium spp..
F. L. Schuster (2002)
Clin. Microbiol. Rev. 15, 355-364
   Abstract »    Full Text »    PDF »
Binding and Invasion of Liver Cells by Plasmodium falciparum Sporozoites. ESSENTIAL INVOLVEMENT OF THE AMINO TERMINUS OF CIRCUMSPOROZOITE PROTEIN.
D. Rathore, J. B. Sacci, P. de la Vega, and T. F. McCutchan (2002)
J. Biol. Chem. 277, 7092-7098
   Abstract »    Full Text »    PDF »
Proteasome Inhibitors Block Development of Plasmodium spp..
S. M. Gantt, J. M. Myung, M. R. S. Briones, W. D. Li, E. J. Corey, S. Omura, V. Nussenzweig, and P. Sinnis (1998)
Antimicrob. Agents Chemother. 42, 2731-2738
   Abstract »    Full Text »


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