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Science 21 August 1981:
Vol. 213. no. 4510, pp. 924 - 926
DOI: 10.1126/science.7256289
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Articles

Science, Vol 213, Issue 4510, 924-926
Copyright © 1981 by American Association for the Advancement of Science

articles

Structural correlates of seizure behavior in the mongolian gerbil

LA Paul, I Fried, K Watanabe, AB Forsythe, and AB Scheibel

Hippocampi of seizure-sensitive and seizure-resistant Mongolian gerbils were examined in search of structural correlates of seizure behavior. In animals with well-established seizure histories, differences were found in both presynaptic and postsynaptic structures. Seizing animals had less dense dendritic spines, a greater proportion of mossy tuft area devoted to presynaptic vesicles, and a smaller proportion devoted to spines. The possible relationship of these findings to epilepsy is discussed.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Evoked Responses of the Dentate Gyrus During Seizures in Developing Gerbils With Inherited Epilepsy.
P. S. Buckmaster and E. H. Wong (2002)
J Neurophysiol 88, 783-793
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Testing the Disinhibition Hypothesis of Epileptogenesis In Vivo and during Spontaneous Seizures.
P. S. Buckmaster, A. L. Jongen-Relo, S. B. Davari, and E. H. Wong (2000)
J. Neurosci. 20, 6232-6240
   Abstract »    Full Text »    PDF »
Spine Loss and Other Persistent Alterations of Hippocampal Pyramidal Cell Dendrites in a Model of Early-Onset Epilepsy.
M. Jiang, C. L. Lee, K. L. Smith, and J. W. Swann (1998)
J. Neurosci. 18, 8356-8368
   Abstract »    Full Text »    PDF »


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