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Science 21 August 1981:
Vol. 213. no. 4510, pp. 913 - 915
DOI: 10.1126/science.6114560
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Articles

Science, Vol 213, Issue 4510, 913-915
Copyright © 1981 by American Association for the Advancement of Science

articles

Depolarization- and ionophore-induced release of octacosa somatostatin from stalk median eminence synaptosomes

CF Kewley, RP Millar, MC Berman, and AV Schally

Species of somatostatin of higher molecular weight were present in the nerve terminals (synaptosomes) of ovine stalk median eminences and were released by depolarizing stimuli. One of these species was identified as the biologically active molecule octacosa somatostatin. Octacosa somatostatin appears therefore to be secreted into the hypothalamic-hypophyseal system, supporting the concept of a role for this peptide in regulating pituitary hormone secretion.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)