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Science 21 August 1981:
Vol. 213. no. 4510, pp. 903 - 905
DOI: 10.1126/science.7196087
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Articles

Science, Vol 213, Issue 4510, 903-905
Copyright © 1981 by American Association for the Advancement of Science

articles

Lateral diffusion of surface molecules in animal cells and tissues

WE Gall and GM Edelman

When bound to cell surfaces, certain lectins such as concanavalin A induce a drop in the average diffusion coefficients (D) of a number of cell surface molecules. To find whether such anchorage modulation occurs naturally, D of surface antigens on different cell and tissue types were measured by fluorescence photobleaching recovery. Values for cells of the same tissue origin under different conditions of growth and association - in tissues, in small aggregates, and as isolated cells - varied by less than twofold when polyspecific monovalent antibodies to cell surface antigens were used, a range much less than the sixfold decrease in D observed after lectin-induced anchorage modulation. Thus, if reversible modulation of the diffusion rate is used naturally as a means of cell signaling, it must involve only a few kinds of surface receptors not detected by the antibodies used in this study. In certain tissues, however, a significant proportion of cells showed no apparent receptor mobility. This "all or none" modulation of lateral diffusion may reflect relatively long-lasting alterations in the states of a single cell type or differentiation among the cells of the particular tissue.


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