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Science 14 August 1981:
Vol. 213. no. 4509, pp. 768 - 770
DOI: 10.1126/science.6266012
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Articles

Science, Vol 213, Issue 4509, 768-770
Copyright © 1981 by American Association for the Advancement of Science

articles

Pituitary gastrins occur in corticotrophs and melanotrophs

LI Larsson and JF Rehfeld

The gut hormone gastrin was identified in pituitary cells containing adrenocorticotropic hormone and alpha-melanocyte--stimulating hormone by region-specific immunocytochemistry and radioimmunoassay. Smaller amounts of gastrin were found in nerve fibers of the neural lobe and pituitary stalk. Since adrenocorticotropic hormone--like peptides occur in antropyloric gastrin cells, these data indicate a considerable similarity in peptide composition of pituitary and gastrointestinal endocrine cells and reinforces questions of multiple hormone production.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The New Biology of Gastrointestinal Hormones.
J. F. REHFELD (1998)
Physiol Rev 78, 1087-1108
   Abstract »    Full Text »    PDF »
Morphine analgesia potentiated but tolerance not affected by active immunization against cholecystokinin.
P. Faris, C. McLaughlin, C. Baile, J. Olney, and B. Komisaruk (1984)
Science 226, 1215-1217
   Abstract »    PDF »


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