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Science 7 August 1981:
Vol. 213. no. 4508, pp. 661 - 663
DOI: 10.1126/science.7256265
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Articles

Science, Vol 213, Issue 4508, 661-663
Copyright © 1981 by American Association for the Advancement of Science

articles

Centrilobular injury following hypoxia in isolated, perfused rat liver

JJ Lemasters, S Ji, and RG Thurman

Hypoxia was produced in isolated, hemoglobin-free, perfused rat liver by reducing the flow rate of oxygen-carrying fluid entering the organ. The procedure caused anoxia in centrilobular regions. In these anoxic areas, structural derangements developed rapidly, characterized by bleb-like protrusions of hepatocyte plasma membrane through fenestrations in the sinusoidal endothelium. Periportal tissue remained normoxic and was completely spared. Cellular injury resulting from localized anoxia may play an important role in the pathogenesis of centrilobular liver disease.


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