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Science 31 July 1981:
Vol. 213. no. 4507, pp. 583 - 585
DOI: 10.1126/science.6264608
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Articles

Science, Vol 213, Issue 4507, 583-585
Copyright © 1981 by American Association for the Advancement of Science

articles

Tolerance and cross-tolerance in chronic alcoholics: reduced membrane binding of ethanol and other drugs

H Rottenberg, A Waring, and E Rubin

Membrane binding of ethanol, anesthetics, and hydrophobic molecules in brain synaptosomes and liver mitochondria from rats is conspicuously reduced after long-term consumption of ethanol. The membranes are resistant to structural disordering by both ethanol and halothane. Tolerance, cross-tolerance, and dependence in chronic alcoholics may in part result from membrane alterations that inhibit the binding of ethanol and other drugs.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
ACUTE EXPOSURE OF CULTURED NEURONES TO ETHANOL RESULTS IN REVERSIBLE DNA SINGLE-STRAND BREAKS; WHEREAS CHRONIC EXPOSURE CAUSES LOSS OF CELL VIABILITY.
F. Lamarche, B. Gonthier, N. Signorini, H. Eysseric, and L. Barret (2003)
Alcohol Alcohol. 38, 550-558
   Abstract »    Full Text »    PDF »
Membrane Fluidity Adjustments in Ethanol-Stressed Oenococcus oeni Cells.
M. G. Da Silveira, E. A. Golovina, F. A. Hoekstra, F. M. Rombouts, and T. Abee (2003)
Appl. Envir. Microbiol. 69, 5826-5832
   Abstract »    Full Text »    PDF »
Ethanol withdrawal in mice precipitated and exacerbated by hyperbaric exposure.
R. Alkana, D. Finn, G. Galleisky, P. Syapin, and R. Malcolm (1985)
Science 229, 772-774
   Abstract »    PDF »
Ethanol modulation of opiate receptors in cultured neural cells.
M. Charness, A. Gordon, and I Diamond (1983)
Science 222, 1246-1248
   Abstract »    PDF »
Lack of correlation between hepatic mitochondrial membrane structure and functions in ethanol-fed rats.
E. Gordon, J Rochman, M Arai, and C. Lieber (1982)
Science 216, 1319-1321
   Abstract »    PDF »
Using Research in Practice: Mechanisms of Drug Tolerance.
B. B. Fuller (1982)
West J Nurs Res 4, 113-118
   PDF »


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