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Science 31 July 1981:
Vol. 213. no. 4507, pp. 581 - 583
DOI: 10.1126/science.6264607
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Articles

Science, Vol 213, Issue 4507, 581-583
Copyright © 1981 by American Association for the Advancement of Science

articles

Delta9-tetrahydrocannabinol increase plasma testosterone concentrations in mice

S Dalterio, A Bartke, and D Mayfield

Oral administration of delta 9-tetrahydrocannabinol had a biphasic effect on plasma testosterone concentrations in male mice, causing rapid sustained increases at low doses and subsequent decreases at higher doses. In hypophysectomized and intact mice receiving gonadotropins (human chorionic gonadotropin), treatment with delta 9-tetrahydrocannabinol maintained higher plasma testosterone concentrations. Thus, this cannabinoid may interact with gonadotropin and directly influence testicular steroidogenesis in vivo.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cannabinoids in male mice: effects on fertility and spermatogenesis.
S Dalterio, F Badr, A Bartke, and D Mayfield (1982)
Science 216, 315-316
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