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Science 31 July 1981:
Vol. 213. no. 4507, pp. 575 - 577
DOI: 10.1126/science.7244656
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Articles

Science, Vol 213, Issue 4507, 575-577
Copyright © 1981 by American Association for the Advancement of Science

articles

Ethanol tolerance in the rat is learned

Wenger JR, TM Tiffany, C Bombardier, K Nicholls, and SC Woods

Rats were trained to walk on a treadmill to avoid foot shock. The animals developed tolerance for ethanol if given subsequent practice while ethanol intoxicated. Rats given equivalent doses of ethanol after practice did not develop tolerance, nor did saline-treated controls. These results challenge the hypothesis that mere repeated doses of ethanol are sufficient to induce tolerance. It seems that tolerance does not develop unless the response used to measure tolerance is performed while the subject is intoxicated.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cellular and molecular mechanisms of drug dependence.
G. Koob and F. Bloom (1988)
Science 242, 715-723
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Subjective Responses to Alcohol in Sons of Alcoholics and Control Subjects.
M. A. Schuckit (1984)
Arch Gen Psychiatry 41, 879-884
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Factors in ethanol tolerance.
B Tabakoff, C. Melchior, and P Hoffman (1984)
Science 224, 523-524
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Factors in Ethanol Tolerance.
J. R. WENGER and S. C. WOODS (1984)
Science 224, 524
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