Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 31 July 1981:
Vol. 213. no. 4507, pp. 571 - 573
DOI: 10.1126/science.7017937
Prev | Table of Contents | Next

Articles

Science, Vol 213, Issue 4507, 571-573
Copyright © 1981 by American Association for the Advancement of Science

articles

Pineal N-acetyltransferase is inactivated by disulfide-containing peptides: insulin is the most potent

MA Namboodiri, JT Favilla, and DC Klein

Pineal N-acetyltransferase can be inactivated in broken cell preparations by cystamine through a mechanism of thiol-disulfide exchange. Some, but not all, disulfide-containing peptides can inactivate this enzyme; the most potent inactivator is insulin. These findings suggest that a disulfide-containing peptide with high reactivity toward N-acetyltransferase may participate in the intracellular regulation of this enzyme.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Generation of the Melatonin Endocrine Message in Mammals: A Review of the Complex Regulation of Melatonin Synthesis by Norepinephrine, Peptides, and Other Pineal Transmitters.
V. Simonneaux and C. Ribelayga (2003)
Pharmacol. Rev. 55, 325-395
   Abstract »    Full Text »    PDF »
An Intramolecular Disulfide Bridge as a Catalytic Switch for Serotonin N-Acetyltransferase.
S. Tsuboi, Y. Kotani, K.'i. Ogawa, T. Hatanaka, S. Yatsushiro, M. Otsuka, and Y. Moriyama (2002)
J. Biol. Chem. 277, 44229-44235
   Abstract »    Full Text »    PDF »
Pineal Serotonin N-Acetyltransferase: Expression Cloning and Molecular Analysis.
S. L. Coon, P. H. Roseboom, R. Baler, J. L. Weller, M. A. A. Namboodiri, E. V. Koonin, and D. C. Klein (1995)
Science 270, 1681-1683
   Abstract »    PDF »
cAMP Regulation of Arylalkylamine N-Acetyltransferase (AANAT, EC 2.3.1.87). A NEW CELL LINE (1E7) PROVIDES EVIDENCE OF INTRACELLULAR AANAT ACTIVATION.
S. L. Coon, J. L. Weller, H.-W. Korf, M. A. A. Namboodiri, M. Rollag, and D. C. Klein (2001)
J. Biol. Chem. 276, 24097-24107
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)