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Science 31 July 1981:
Vol. 213. no. 4507, pp. 565 - 567
DOI: 10.1126/science.6941477
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Articles

Science, Vol 213, Issue 4507, 565-567
Copyright © 1981 by American Association for the Advancement of Science

articles

Tumor-induced anorexia in the Wistar rat

JP Mordes and AA Rossini

The transplantable Leydig cell tumor of Wistar rats, LTW(m), caused decreased food consumption and weight loss in the host within 2 weeks of implantation. The tumor was small, did not metastasize, and did not affect several parameters of biochemical function. When the tumors were removed, increases in food intake and body weight occurred within 72 hours and were sustained. Reimplantation of tumors caused anorexia to recur. Parabiotic pairs of rats with tumor in one partner also experienced weight loss. Those rats in parabiosis with tumor-bearing rats gained less weight than those in parabiosis with control rats. These observations suggest that the LTW(m) tumor causes anorexia and that this anorexia is mediated by a circulating substance.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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J. Neurosci. 20, 8637-8642
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Parenteral Nutrition and Metabolic Observations in Cancer.
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Science. ISSN 0036-8075 (print), 1095-9203 (online)