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Science 31 July 1981:
Vol. 213. no. 4507, pp. 551 - 553
DOI: 10.1126/science.7244653
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Articles

Science, Vol 213, Issue 4507, 551-553
Copyright © 1981 by American Association for the Advancement of Science

articles

Diameter of the cell-to-cell junctional membrane channels as probed with neutral molecules

G Schwarzmann, H Wiegandt, B Rose, A Zimmerman, D Ben-Haim, and WR Loewenstein

The cell-to-cell channels in the junctions of an insect salivary gland and of insect and mammalian cells in culture were probed with fluorescent molecules-neutral linear oligosaccharides, neutral branched glycopeptides, and charged linear peptides. From the molecular dimensions of the largest permeants and smallest impermeants the permeation-limiting channel diameter was obtained: 16 to 20 angstroms for the mammalian cells and 20 to 30 angstroms for the insect cells.


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