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Science 31 July 1981:
Vol. 213. no. 4507, pp. 546 - 549
DOI: 10.1126/science.6264605
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Articles

Science, Vol 213, Issue 4507, 546-549
Copyright © 1981 by American Association for the Advancement of Science

articles

Benzodiazepine inhibition of the calcium-calmodulin protein kinase system in brain membrane

RJ DeLorenzo, S Burdette, and J Holderness

Benzodiazepines inhibit Ca2+-calmodulin-stimulated membrane protein phosphorylation. The effects of the benzodiazepines on protein phosphorylation are stereospecific and produced by membrane-bound benzodiazepine. The potency of benzodiazepine kinase inhibition is correlated with the ability of the benzodiazepines to inhibit electric shock-induced convulsions. These findings provide evidence that some of the anticonvulsant and neuronal stabilizing effects of benzodiazepines may be modulated by the Ca2+-calmodulin protein kinase system and indicate that this calmodulin-kinase system represents an identifiable benzodiazepine receptor in brain that is distinquishable by several criteria from the previously described high affinity benzodiazepine receptor.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Platelet-activating factor-induced aggregation of human platelets specifically inhibited by triazolobenzodiazepines.
E Kornecki, Y. Ehrlich, and R. Lenox (1984)
Science 226, 1454-1456
   Abstract »    PDF »
Micromolar affinity benzodiazepine receptors: identification and characterization in central nervous system.
A. Bowling and R. DeLorenzo (1982)
Science 216, 1247-1250
   Abstract »    PDF »


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