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Science 24 July 1981:
Vol. 213. no. 4506, pp. 447 - 449
DOI: 10.1126/science.6264601
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Articles

Science, Vol 213, Issue 4506, 447-449
Copyright © 1981 by American Association for the Advancement of Science

articles

Viral epitopes and monoclonal antibodies: isolation of blocking antibodies that inhibit virus neutralization

RJ Massey and G Schochetman

The inability of pathogenic animal viruses to be completely neutralized by antibodies can lead to chronic viral infections in which infectious virus persists even in the presence of excess neutralizing antibody. A mechanism that results in this nonneutralized fraction of virus was defined by the topographical relationships of viral epitopes identified with monoclonal antibodies wherein monoclonal antibodies bind to virus and sterically block the binding of neutralizing antibodies.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Occupancy and mechanism in antibody-mediated neutralization of animal viruses.
P. J. Klasse and Q. J. Sattentau (2002)
J. Gen. Virol. 83, 2091-2108
   Abstract »    Full Text »    PDF »
Additive Effects Characterize the Interaction of Antibodies Involved in Neutralization of the Primary Dualtropic Human Immunodeficiency Virus Type 1 Isolate 89.6.
F. Verrier, A. Nadas, M. K. Gorny, and S. Zolla-Pazner (2001)
J. Virol. 75, 9177-9186
   Abstract »    Full Text »    PDF »


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