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Science 24 July 1981:
Vol. 213. no. 4506, pp. 406 - 411
DOI: 10.1126/science.6264599
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Articles

Science, Vol 213, Issue 4506, 406-411
Copyright © 1981 by American Association for the Advancement of Science

articles

Biology of hepatitis B virus

P Tiollais, P Charnay, and GN Vyas

Immunochemical investigations of the viral antigens and molecular characterization of the viral DNA have elucidated the nature of the hepatitis B virus infection underlying acute, chronic, and oncogenic disorders of the liver in man. Cloning and sequencing of viral DNA have made possible studies on the structure of the genome and on certain aspects of the biology of the virus, hitherto constrained for a lack of tissue culture systems and laboratory animal models useful in its propagation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A Genetic Variant of Hepatitis B Virus Divergent from Known Human and Ape Genotypes Isolated from a Japanese Patient and Provisionally Assigned to New Genotype J.
K. Tatematsu, Y. Tanaka, F. Kurbanov, F. Sugauchi, S. Mano, T. Maeshiro, T. Nakayoshi, M. Wakuta, Y. Miyakawa, and M. Mizokami (2009)
J. Virol. 83, 10538-10547
   Abstract »    Full Text »    PDF »
Hepatitis B Virus Replication Is Associated with an HBx-Dependent Mitochondrion-Regulated Increase in Cytosolic Calcium Levels.
S. L. McClain, A. J. Clippinger, R. Lizzano, and M. J. Bouchard (2007)
J. Virol. 81, 12061-12065
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The Hepatitis B Virus X Protein Inhibits Secretion of Apolipoprotein B by Enhancing the Expression of N-Acetylglucosaminyltransferase III.
S.-K. Kang, T.-W. Chung, J.-Y. Lee, Y.-C. Lee, R. E. Morton, and C.-H. Kim (2004)
J. Biol. Chem. 279, 28106-28112
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Hepatitis B Virus X Protein Modulates the Expression of PTEN by Inhibiting the Function of p53, a Transcriptional Activator in Liver Cells.
T.-W. Chung, Y.-C. Lee, J.-H. Ko, and C.-H. Kim (2003)
Cancer Res. 63, 3453-3458
   Abstract »    Full Text »    PDF »
Hepatitis B viral core proteins with an N-terminal extension can assemble into core-like particles but cannot be enveloped.
E. K.-W. Hui, Y. S. Yi, and S. J. Lo (1999)
J. Gen. Virol. 80, 2647-2659
   Abstract »    Full Text »
Hepatitis B virus maturation is affected by the incorporation of core proteins having a C-terminal substitution of arginine or lysine stretches.
E. K.-W. Hui, K.-L. Chen, and S. J. Lo (1999)
J. Gen. Virol. 80, 2661-2671
   Abstract »    Full Text »
Prevention of Hepatitis B in Surgeons and Their Patients.
C. E. Reese and R. K. Ockner (1989)
Perspectives in Vascular Surgery and Endovascular Therapy 2, 138-147
   PDF »
Anti-idiotypic antibody vaccine for type B viral hepatitis in chimpanzees.
R. Kennedy, J. Eichberg, R. Lanford, and G. Dreesman (1986)
Science 232, 220-223
   Abstract »    PDF »
Enhanced immunogenicity of the pre-S region of hepatitis B surface antigen.
D. Milich, G. Thornton, A. Neurath, S. Kent, M. Michel, P Tiollais, and F. Chisari (1985)
Science 228, 1195-1199
   Abstract »    PDF »
Antibodies to peptides detect new hepatitis B antigen: serological correlation with hepatocellular carcinoma.
A. Moriarty, H Alexander, R. Lerner, and G. Thornton (1985)
Science 227, 429-433
   Abstract »    PDF »
Location and chemical synthesis of a pre-S gene coded immunodominant epitope of hepatitis B virus.
A. Neurath, S. Kent, and N Strick (1984)
Science 224, 392-395
   Abstract »    PDF »
Antibodies to hepatitis B surface antigen potentiate the response of human T lymphocyte clones to the same antigen.
E Celis and T. Chang (1984)
Science 224, 297-299
   Abstract »    PDF »
Antibody to hepatitis B virus induced by injecting antibodies to the idiotype.
R. Kennedy, J. Melnick, and G. Dreesman (1984)
Science 223, 930-931
   Abstract »    PDF »
Hepatitis B virus infection in cultured human lymphoblastoid cells.
J. Romet-Lemonne, M. McLane, E Elfassi, W. Haseltine, J Azocar, and M Essex (1983)
Science 221, 667-669
   Abstract »    PDF »
Viral Hepatitis.
J. A. Payne (1982)
Arch Dermatol 118, 945-948
   Abstract »    PDF »
Is hepatitis B virus a retrovirus in disguise?.
J. Marx (1982)
Science 217, 1021-1022
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