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Science 17 July 1981:
Vol. 213. no. 4505, pp. 346 - 347
DOI: 10.1126/science.7244619
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Articles

Science, Vol 213, Issue 4505, 346-347
Copyright © 1981 by American Association for the Advancement of Science

articles

Carcinogenicity in mice of mutagenic compounds from a tryptophan pyrolyzate

N Matsukura, T Kawachi, K Morino, H Ohgaki, T Sugimura, and S Takayama

The compounds 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole and 3-amino-1-methyl-5H-pyrido[4,3-b]indole, which are potent mutagens in a tryptophan pyrolyzate, ar hepatic carcinogens when given orally to mice at concentrations of 200 parts per million in a pellet diet. Female mice showed higher susceptibilities to both compounds than male mice.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) triggers apoptosis by DNA double-strand breaks caused by inhibition of topoisomerase I.
B. Shiotani and H. Ashida (2004)
Carcinogenesis 25, 1149-1155
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A test of the mutagenicity of cooked meats in vivo.
J. A. Heddle, M. G. Knize, D. Dawod, and X.-B. Zhang (2001)
Mutagenesis 16, 103-107
   Abstract »    Full Text »    PDF »
Chasing A Receding Zero: Impact of the Zero Threshold Concept on Actions of Regulatory Officials.
T. H. Jukes (1983)
International Journal of Toxicology 2, 147-160
   Abstract »    PDF »


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