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Science 10 July 1981:
Vol. 213. no. 4504, pp. 244 - 246
DOI: 10.1126/science.7244635
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Articles

Science, Vol 213, Issue 4504, 244-246
Copyright © 1981 by American Association for the Advancement of Science

articles

Brain 5beta-reductase: a correlate of behavioral sensitivity to androgen

JB Hutchison and T Steimer

Testosterone is converted in the dove (Streptopelia risoria) brain to 5 beta-reduced metabolites that do not affect behavior. In long-term castrated birds, which are relatively insensitive to the behavioral effects of testosterone, the activity of preoptic 5 beta-reductase is increased. The increase, which is specific to the preoptic area, is reversed by estrogen. Inactivation of testosterone by 5 beta-reduction may be involved in the control of brain sensitivity to androgen.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Contributions of bird studies to biology.
M Konishi, S. Emlen, R. Ricklefs, and J. Wingfield (1989)
Science 246, 465-472
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