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Science 10 July 1981:
Vol. 213. no. 4504, pp. 226 - 228
DOI: 10.1126/science.6264598
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Articles

Science, Vol 213, Issue 4504, 226-228
Copyright © 1981 by American Association for the Advancement of Science

articles

Three distinct genes in human DNA related to the transforming genes of mammalian sarcoma retroviruses

F Wong-Staal, R Dalla-Favera, G Franchini, EP Gelmann, and RC Gallo

Southern blot hybridization was used to identify human and other vertebrate DNA sequences that were homologous to cloned DNA fragments containing the oncogenic nucleic acid sequences of three different type C mammalian retroviruses (simian sarcoma virus, the Snyder-Theilen strain of feline sarcoma virus, and the Harvey strain of murine sarcoma virus). Each onc gene counterpart has a single genetic locus, which probably contains non-onc intervening sequences. The human DNA sequences may represent genes important to cell growth or cell differentiation, or both. Their identification and isolation may allow elucidation of their role in these processes and in neoplasias.


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Expression of cellular oncogenes in human malignancies.
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Science 224, 256-262
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5' viral and human cellular sequences corresponding to the transforming gene of simian sarcoma virus.
S. Josephs, R Dalla-Favera, E. Gelmann, R. Gallo, and F Wong-Staal (1983)
Science 219, 503-505
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Chromosomal localization of the human homolog (c-sis) of the simian sarcoma virus onc gene.
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