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Science 10 July 1981:
Vol. 213. no. 4504, pp. 218 - 219
DOI: 10.1126/science.6264597
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Articles

Science, Vol 213, Issue 4504, 218-219
Copyright © 1981 by American Association for the Advancement of Science

articles

Epidermal growth factors enhances viral transformation of granulosa cells

J Harrison and N Auersperg

Kirsten sarcoma virus produced a low incidence of transient morphological transformation in primary cultures of rat ovarian granulosa cells. In the presence of epidermal growth factor, the incidence of transient transformation increased severalfold and two continuous cell lines were established. Epidermal growth factor, a naturally occurring polypeptide hormone, appears to act here as a tumor promoter in the retrovirus-induced transformation of a mesodermally derived epithelium.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Control of Differentiation, Transformation, and Apoptosis in Granulosa Cells by Oncogenes, Oncoviruses, and Tumor Suppressor Genes.
A. Amsterdam and N. Selvaraj (1997)
Endocr. Rev. 18, 435-461
   Abstract »    Full Text »    PDF »
Potential Role of Intercellular Communication in the Rate-Limiting Step in Carcinogenesis.
J. E. Trosko and C.-c. Chang (1983)
International Journal of Toxicology 2, 5-22
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)