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Science 26 June 1981:
Vol. 212. no. 4502, pp. 1533 - 1534
DOI: 10.1126/science.7233244
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Articles

Science, Vol 212, Issue 4502, 1533-1534
Copyright © 1981 by American Association for the Advancement of Science

articles

Morphine-induced attenuation of morphine tolerance

S Siegel, RE Hinson, and MD Krank

Rats experienced both morphine and an environmental cue, but the cue always signaled a drug-free period. They were subsequently administered morphine in the presence of the cue, and the development of analgesic tolerance was assessed. The prior experience retarded such tolerance. The finding that a procedure of opiate administration can retard opiate tolerance suggests that an association between cues preceding the drug and the drug itself contributes to tolerance.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The effect of the CS-UCS interval and extinction on place conditioning and analgesic tolerance with morphine.
R. E. Hinson, S. A. McKee, T. Lovenjak, and A.-M. Wall (1993)
J Psychopharmacol 7, 164-172
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Integrating psychology and pharmacology in the management of anxiety: a reply to 'Psychology and pharmacology in the treatment of anxiety disorders'.
J. Wardle (1991)
J Psychopharmacol 5, 293-295
   PDF »
Pavlovian conditional tolerance to haloperidol catalepsy: evidence of dynamic adaptation in the dopaminergic system.
C. Poulos and R Hinson (1982)
Science 218, 491-492
   Abstract »    PDF »
Using Research in Practice: Mechanisms of Drug Tolerance.
B. B. Fuller (1982)
West J Nurs Res 4, 113-118
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Science. ISSN 0036-8075 (print), 1095-9203 (online)