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Science 26 June 1981:
Vol. 212. no. 4502, pp. 1531 - 1533
DOI: 10.1126/science.7233243
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Articles

Science, Vol 212, Issue 4502, 1531-1533
Copyright © 1981 by American Association for the Advancement of Science

articles

Exposure of rats to alcohol in utero alters drug sensitivity in adulthood

EL Abel, R Bush, and BA Dintcheff

Pregnant rats were intubated with alcohol (ethanol, 3 grams per kilogram) twice daily throughout gestation. Control animals received solutions of isocaloric sucrose. At birth, offspring were placed with untreated surrogate dams. Beginning at 6 months of age, the offspring were tested for their thermogenic responsiveness to various drugs and to cold. Prenatal exposure to alcohol resulted in tolerance to alcohol and cross-tolerance to pentobarbital and diazepam but did not affect responsiveness to cold. This pattern of effects suggest that prenatal exposure to alcohol produces specific long-term effects on the neural mechanisms underlying drug tolerance.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A 21-Year Longitudinal Analysis of the Effects of Prenatal Alcohol Exposure on Young Adult Drinking.
J. S. Baer, P. D. Sampson, H. M. Barr, P. D. Connor, and A. P. Streissguth (2003)
Arch Gen Psychiatry 60, 377-385
   Abstract »    Full Text »    PDF »
Subjective Responses to Alcohol in Sons of Alcoholics and Control Subjects.
M. A. Schuckit (1984)
Arch Gen Psychiatry 41, 879-884
   Abstract »    PDF »
Using Research in Practice: Mechanisms of Drug Tolerance.
B. B. Fuller (1982)
West J Nurs Res 4, 113-118
   PDF »


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