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Science 26 June 1981:
Vol. 212. no. 4502, pp. 1518 - 1520
DOI: 10.1126/science.7233238
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Articles

Science, Vol 212, Issue 4502, 1518-1520
Copyright © 1981 by American Association for the Advancement of Science

articles

Immunization of Baboons with Schistosoma mansoni Cercariae attenuated by gamma irradiation

M F Stek, P Minard, DA Dean, and JE Hall

Studies on the efficacy of a vaccine against schistosomiasis in young baboons (Papio anubis) disclosed that immunization with Schistosoma mansoni cercariae attenuated by gamma irradiation induced significant protection against subsequent infection with normal, viable S. mansoni cercariae. Such immunization resulted in reduced worm burdens (70 percent) and egg excretion rates (82 percent). These results support immunization as a potential method for schistosomiasis control.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)