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Science 26 June 1981:
Vol. 212. no. 4502, pp. 1514 - 1516
DOI: 10.1126/science.7233237
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Articles

Science, Vol 212, Issue 4502, 1514-1516
Copyright © 1981 by American Association for the Advancement of Science

articles

Metastatic potential is positively correlated with cell surface sialylation of cultured murine tumor cell lines

G Yogeeswaran and PL Salk

The ability of murine tumor cells to metastasize spontaneously from subcutaneous sites is positively correlated with the total sialic acid content of the cells in culture, the degree to which the sialic acid is exposed on the tumor cell surface, and, most strongly, with the degree of sialylation of galactosyl and N-acetylgalactosaminyl residues in cell surface glycoconjugates. These findings suggest that sialic acid on the cell surface may play a role in tumor cell metastasis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Hexapeptide Inhibitor of Galbeta 1,3GalNAc-specific alpha 2,3-Sialyltransferase as a Generic Inhibitor of Sialyltransferases.
K.-Y. Lee, H. G. Kim, M. R. Hwang, J. I. Chae, J. M. Yang, Y. C. Lee, Y. K. Choo, Y. I. Lee, S.-S. Lee, and S.-I. Do (2002)
J. Biol. Chem. 277, 49341-49351
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Up-regulation of plasma membrane-associated ganglioside sialidase (Neu3) in human colon cancer and its involvement in apoptosis suppression.
Y. Kakugawa, T. Wada, K. Yamaguchi, H. Yamanami, K. Ouchi, I. Sato, and T. Miyagi (2002)
PNAS 99, 10718-10723
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Role of Carcinoembryonic Antigen in the Progression of Colon Cancer Cells That Express Carbohydrate Antigen.
S. Minami, J. Furui, and T. Kanematsu (2001)
Cancer Res. 61, 2732-2735
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Anoikis and Metastatic Potential of Cloudman S91 Melanoma Cells.
Z. Zhu, O. Sanchez-Sweatman, X. Huang, R. Wiltrout, R. Khokha, Q. Zhao, and E. Gorelik (2001)
Cancer Res. 61, 1707-1716
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UDP-GlcNAc 2-Epimerase: A Regulator of Cell Surface Sialylation.
O. T. Keppler, S. Hinderlich, J. Langner, R. Schwartz-Albiez, W. Reutter, and M. Pawlita (1999)
Science 284, 1372-1376
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Transcriptional Regulation of the N-Acetylglucosaminyltransferase V Gene in Human Bile Duct Carcinoma Cells (HuCC-T1) Is Mediated by Ets-1.
R. Kang, H. Saito, Y. Ihara, E. Miyoshi, N. Koyama, Y. Sheng, and N. Taniguchi (1996)
J. Biol. Chem. 271, 26706-26712
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Swainsonine Augments the Cytotoxicity of Human Lymphokine-Activated Killer Cells Against Autologous Thyroid Cancer Cells.
S. Fujieda, I. Noda, H. Saito, T. Hoshino, and M. Yagita (1994)
Arch Otolaryngol Head Neck Surg 120, 389-394
   Abstract »    PDF »
Inhibition of Sialic Acid Incorporation Prevents Hepatic Metastases.
H. E. Wagner, P. Thomas, B. C. Wolf, A. Rapoza, and G. Steele Jr (1990)
Arch Surg 125, 351-354
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Experimental Liver Metastasis: Implications of Clonal Proclivity and Organ Specificity.
T. S. Ravikumar, J. D'Emilia, C. Cocchiaro, B. Wolf, V. King, and G. Steele Jr (1989)
Arch Surg 124, 49-54
   Abstract »    PDF »
Metastatic Choroidal Melanoma: Hepatic Binding Protein Reactivity Toward a Liver-Metastasizing Clone.
L. A. Donoso, R. M. Nagy, MS, R. C. McFall, K. E. Edelberg, and D. G. Vossler (1983)
Arch Ophthalmol 101, 787-790
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3'-Azidothymidine Potently Inhibits the Biosynthesis of Highly Branched N-Linked Oligosaccharides and Poly-N-acetyllactosamine Chains in Cells.
R. A. Steet, P. Melancon, and R. D. Kuchta (2000)
J. Biol. Chem. 275, 26812-26820
   Abstract »    Full Text »    PDF »


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