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Science 19 June 1981:
Vol. 212. no. 4501, pp. 1407 - 1408
DOI: 10.1126/science.7233230
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Articles

Science, Vol 212, Issue 4501, 1407-1408
Copyright © 1981 by American Association for the Advancement of Science

articles

Myelination of central nervous system axons in tissue culture by transplanted oligodendrocytes

F Seil and NK Blank

Unmyelinated mouse cerebellar cerebellar cultures in which oligodendrocyte differentiation had been suppressed by exposure to cytosine arabinoside developed axonal myelin after superimposition of kainic acid-treated cerebellar explants devoid of myelin-receptive axons. The latter explants contained differentiated oligodendrocytes. The operation of a diffusible myelin-stimulating factor was ruled out by the failure of myelination in cytosine arabinoside-exposed explants not in direct contact with oligodendrocyte-containing transplants.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)