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Science 12 June 1981:
Vol. 212. no. 4500, pp. 1294 - 1296
DOI: 10.1126/science.7233221
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Articles

Science, Vol 212, Issue 4500, 1294-1296
Copyright © 1981 by American Association for the Advancement of Science

articles

Serum lipoproteins modulate oxygenated sterol insertion into human red cell membranes

RA Streuli, J Chung, AM Scanu, and S Yachnin

The insertion of oxygenated sterol compounds into human red blood cell membranes as well as the consequent transformation of the red cells to an echinocyte shape and the expansion of the membranes are impeded by the presence of serum lipoproteins in the incubation medium. All density classes of human serum lipoproteins bind oxygenated sterol compounds, and lipoproteins can act as acceptors of oxygenated sterols previously inserted into red cells. Since oxygenated sterols have been reported to be atherogenic, the modulating and possibly protective effects of serum lipoproteins on oxygenated sterol-induced derangement of cell membrane structure and function may provide a useful model for further study.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Lipoproteins Regulate C-Type Natriuretic Peptide Secretion From Cultured Vascular Endothelial Cells.
S. Sugiyama, K. Kugiyama, T. Matsumura, S.-i. Suga, H. Itoh, K. Nakao, and H. Yasue (1995)
Arterioscler Thromb Vasc Biol 15, 1968-1974
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