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Science 12 June 1981:
Vol. 212. no. 4500, pp. 1279 - 1281
DOI: 10.1126/science.6262917
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Articles

Science, Vol 212, Issue 4500, 1279-1281
Copyright © 1981 by American Association for the Advancement of Science

articles

Somatomedin-C mediates growth hormone negative feedback by effects on both the hypothalamus and the pituitary

M Berelowitz, M Szabo, LA Frohman, S Firestone, L Chu, and RL Hintz

Somatomedin-C stimulates somatostatin release to a maximum of 390 percent of basal release during short-term (20-minute) incubation of rat hypothalamus. It has no effect on basal or stimulated growth hormone release from primary cultures of rat adenohypophyseal cells during a 4-hour incubation, but inhibits stimulated release by more that 90 percent after 24 hours. These findings suggest that somatomedin-C participates in the growth hormone negative feedback loop with an immediate effect on hypothalamic somatostatin and a delayed effect on the anterior pituitary.


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Insulin-like growth factors: a role in growth hormone negative feedback and body weight regulation via brain.
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