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Science 12 June 1981:
Vol. 212. no. 4500, pp. 1270 - 1272
DOI: 10.1126/science.7015512
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Articles

Science, Vol 212, Issue 4500, 1270-1272
Copyright © 1981 by American Association for the Advancement of Science

articles

Prostacyclin: a potent antimetastatic agent

KV Honn, B Cicone, and A Skoff

Metastasis is the principal cause of failures to cure human cancers. Prostacyclin is a powerful antimetastatic agent against B16 amelanotic melanoma cells. This effect, which may result from the platelet antiaggregatory action of prostacyclin, is potentiated by a phosphodiesterase inhibitor. Inhibitors of prostacyclin synthesis increase metastasis. Prostacyclin and agents that may increase endogenous prostacyclin production or prolong its activity are suggested as new antimetastatic agents.


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Tumor cell-platelet aggregation: induced by cathepsin B-like proteinase and inhibited by prostacyclin.
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Role of Platelets in Tumor Cell Metastases.
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