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Science 5 June 1981:
Vol. 212. no. 4499, pp. 1170 - 1172
DOI: 10.1126/science.7233212
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Articles

Science, Vol 212, Issue 4499, 1170-1172
Copyright © 1981 by American Association for the Advancement of Science

articles

Gallamine triethiodide (flaxedil): tetraethylammonium- and pancuronium-like effects in myelinated nerve fibers

KJ Smith and CL Schauf

Gallamine triethiodide (Flaxedil) is commonly used as a neuromuscular blocking agent. Voltage-clamp studies show that gallamine also directly affects amphibian and mammalian myelinated nerve fibers. Externally, gallamine is about five times more potent than tetraethylammonium in blocking potassium conductance, where this is present, but has no effect on the sodium channel. Internal application slows sodium inactivation, which in addition is often incomplete. At positive potentials, gallamine can occlude sodium channels, thereby almost eliminating outward sodium currents.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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K. J. Smith, P. A. Felts, and G. R. John (2000)
Brain 123, 171-184
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