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Science 5 June 1981:
Vol. 212. no. 4499, pp. 1169 - 1170
DOI: 10.1126/science.7233211
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Articles

Science, Vol 212, Issue 4499, 1169-1170
Copyright © 1981 by American Association for the Advancement of Science

articles

Genetically determined deficiency of the third component of complement in the dog

JA Winkelstein, LC Cork, DE Griffin, JW Griffin, RJ Adams, and DL Price

A genetically determined deficiency of the third component of complement (C3) has been identified in a colony of Brittany spaniels. Immunochemical methods show no detectable C3 in the serum of the affected dogs, and there is no evidence of an inhibitor of C3 in the serum. The C3 deficiency appears to be transmitted as an autosomal recessive trait.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Molecular Analysis of the Third Component of Canine Complement (C3) and Identification of the Mutation Responsible for Hereditary Canine C3 Deficiency.
R. Ameratunga, J. A. Winkelstein, L. Brody, M. Binns, L. C. Cork, P. Colombani, and D. Valle (1998)
J. Immunol. 160, 2824-2830
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Science. ISSN 0036-8075 (print), 1095-9203 (online)