Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 5 June 1981:
Vol. 212. no. 4499, pp. 1167 - 1168
DOI: 10.1126/science.7195072
Prev | Table of Contents | Next

Articles

Science, Vol 212, Issue 4499, 1167-1168
Copyright © 1981 by American Association for the Advancement of Science

articles

Intravenous self-administration of nomifensine in rats: implications for abuse potential in humans

C Spyraki and HC Fibiger

Rats acquired and maintained intravenous self-administration of nomifensine, a new antidepressant compound. Additional experiments implicated dopamine-containing neurons in this behavior. These findings, along with the marked pharmacological similarities between nomifensine and such drugs as cocaine and methylphenidate, indicate a potential for nomifensine abuse by humans.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Differential Regulation of Dopamine Transporter after Chronic Self-administration of Bupropion and Nomifensine.
S. R. Tella, B. Ladenheim, and J. L. Cadet (1997)
J. Pharmacol. Exp. Ther. 281, 508-513
   Abstract »    Full Text »
Is Methylphenidate Like Cocaine? Studies on Their Pharmacokinetics and Distribution in the Human Brain.
N. D. Volkow, Y.-S. Ding, J. S. Fowler, G.-J. Wang, J. Logan, J. S. Gatley, S. Dewey, C. Ashby, J. Liebermann, R. Hitzemann, et al. (1995)
Arch Gen Psychiatry 52, 456-463
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)