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Science 5 June 1981:
Vol. 212. no. 4499, pp. 1159 - 1162
DOI: 10.1126/science.6165082
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Articles

Science, Vol 212, Issue 4499, 1159-1162
Copyright © 1981 by American Association for the Advancement of Science

articles

DNA sequence of two closely linked human leukocyte interferon genes

RM Lawn, J Adelman, TJ Dull, M Gross, D Goeddel, and A Ullrich

A single recombinant lambda bacteriophage isolated from a human genome library contains two closely related human interferon genes of the leukocyte or alpha type. The two genes are separated by 12 kilobase pairs and are oriented in the same direction with respect to transcription. Comparisons of the DNA sequences of these two genes and interferon complementary DNA clones indicate that the two interferon genes lack intervening sequences.


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