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Science 5 June 1981:
Vol. 212. no. 4499, pp. 1157 - 1159
DOI: 10.1126/science.6785885
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Articles

Science, Vol 212, Issue 4499, 1157-1159
Copyright © 1981 by American Association for the Advancement of Science

articles

Divalent cation ionophores stimulate resorption and inhibit DNA synthesis in cultured fetal rat bone

JA Lorenzo and LG Raisz

Two divalent cation ionophores, A23187 and Ionomycin, which are selective for calcium, stimulated the resorption of fetal rat long bones in organ culture at 0.1 to 1 micromolar but not at higher concentrations. Both agents inhibited DNA synthesis at concentrations that stimulated resorption. These results might explain the differences in ionophore effects on bone previously reported, and they imply that cell replication is not required for osteoclast formation in fetal rat long bone cultures.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Intracellular Calcium and Protein Kinase C Mediate Expression of Receptor Activator of Nuclear Factor-{{kappa}}B Ligand and Osteoprotegerin in Osteoblasts.
M. Takami, N. Takahashi, N. Udagawa, C. Miyaura, K. Suda, J.-T. Woo, T. J. Martin, K. Nagai, and T. Suda (2000)
Endocrinology 141, 4711-4719
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Science. ISSN 0036-8075 (print), 1095-9203 (online)