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Science 5 June 1981:
Vol. 212. no. 4499, pp. 1155 - 1157
DOI: 10.1126/science.6262914
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Articles

Science, Vol 212, Issue 4499, 1155-1157
Copyright © 1981 by American Association for the Advancement of Science

articles

Calcium spike electrogenesis and other electrical activity in continuously cultured small cell carcinoma of the lung

FV McCann, OS Pettengill, JJ Cole, JA Russell, and GD Sorenson

Spike electrogenesis, local depolarizing and hyperpolarizing responses, spontaneous rhythmic firing, and alternating resting potentials were measured in cells from a continuously cultured small cell carcinoma of the lung. Spike generation was blocked by MnCl2. In view of this evidence for calcium-spike electrogenesis and previous evidence of secretory activity in these cells, this cell line (DMS 53) can provide a model for the study of excitation-secretion behavior in human neoplastic cells.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Calcium-Channel Antibodies in the Lambert-Eaton Syndrome and Other Paraneoplastic Syndromes.
V. A. Lennon, T. J. Kryzer, G. E. Griesmann, P. E. O'Suilleabhain, A. J. Windebank, A. Woppmann, G. P. Miljanich, and E. H. Lambert (1995)
N. Engl. J. Med. 332, 1467-1475
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Science. ISSN 0036-8075 (print), 1095-9203 (online)