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Science 5 June 1981:
Vol. 212. no. 4499, pp. 1151 - 1153
DOI: 10.1126/science.7233209
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Articles

Science, Vol 212, Issue 4499, 1151-1153
Copyright © 1981 by American Association for the Advancement of Science

articles

Lysosomal cathepsin B: correlation with metastatic potential

BF Sloane, Dunn JR, and KV Honn

Although lysosomal enzymes are implicated in the processes of tumor invasion and metastasis, their cellular origin within the tumor is unclear. The activity of the lysosomal proteinase cathepsin B is significantly elevated in a variant of the B16 melanoma with high metastatic potential. The cathepsin B activity is localized to the lysosomes of the tumor cells.


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Cannibalism of live lymphocytes by human metastatic but not primary melanoma cells..
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Cathepsin S Controls Angiogenesis and Tumor Growth via Matrix-derived Angiogenic Factors.
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1{alpha},25-dihydroxyvitamin D3 inhibits prostate cancer cell invasion via modulation of selective proteases.
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Role of cathepsins and cystatins in patients with recurrent miscarriage.
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Human Procathepsin B Interacts with the Annexin II Tetramer on the Surface of Tumor Cells.
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Cysteine Proteinases and the Pathogenesis of Amebiasis.
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Mosquito Cathepsin B-like Protease Involved in Embryonic Degradation of Vitellin Is Produced as a Latent Extraovarian Precursor.
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Inhibition of Metastases by Anticoagulants.
M. Hejna, M. Raderer, and C. C. Zielinski (1999)
J Natl Cancer Inst 91, 22-36
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Cathepsin Z, a Novel Human Cysteine Proteinase with a Short Propeptide Domain and a Unique Chromosomal Location.
I. Santamaria, G. Velasco, A. M. Pendas, A. Fueyo, and C. Lopez-Otin (1998)
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Immunofluorometric assay of pepsinogen C and preliminary clinical applications.
E. P. Diamandis, S. Nadkarni, B. Bhaumik, A. Abdelrahman, D. N. Melegos, G. Borchert, M. H. Black, M. Alonso, A. Salas, J. R. de los Toyos, et al. (1997)
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Hormonal Regulation of the Human Pepsinogen C Gene in Breast Cancer Cells. IDENTIFICATION OF A CIS-ACTING ELEMENT MEDIATING ITS INDUCTION BY ANDROGENS, GLUCOCORTICOIDS, AND PROGESTERONE.
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Isolation of a High Affinity Inhibitor of Urokinase-type Plasminogen Activator by Phage Display of Ecotin.
C.-I W. Q. Y. and Charles S. Craik and C. I. Wang (1995)
J. Biol. Chem. 270, 12250-12256
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Heparan sulfate degradation: relation to tumor invasive and metastatic properties of mouse B16 melanoma sublines.
M Nakajima, T Irimura, D Di Ferrante, N Di Ferrante, and G. Nicolson (1983)
Science 220, 611-613
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Tumor cell-platelet aggregation: induced by cathepsin B-like proteinase and inhibited by prostacyclin.
K. Honn, P Cavanaugh, C Evens, J. Taylor, and B. Sloane (1982)
Science 217, 540-542
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Prostacyclin: a potent antimetastatic agent.
K. Honn, B Cicone, and A Skoff (1981)
Science 212, 1270-1272
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