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Science 5 June 1981:
Vol. 212. no. 4499, pp. 1151 - 1153
DOI: 10.1126/science.7233209
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Articles

Science, Vol 212, Issue 4499, 1151-1153
Copyright © 1981 by American Association for the Advancement of Science

articles

Lysosomal cathepsin B: correlation with metastatic potential

BF Sloane, Dunn JR, and KV Honn

Although lysosomal enzymes are implicated in the processes of tumor invasion and metastasis, their cellular origin within the tumor is unclear. The activity of the lysosomal proteinase cathepsin B is significantly elevated in a variant of the B16 melanoma with high metastatic potential. The cathepsin B activity is localized to the lysosomes of the tumor cells.


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