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Science 29 May 1981:
Vol. 212. no. 4498, pp. 1030 - 1032
DOI: 10.1126/science.6165080
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Articles

Science, Vol 212, Issue 4498, 1030-1032
Copyright © 1981 by American Association for the Advancement of Science

articles

Interferon action: RNA cleavage pattern of a (2'-5')oligoadenylate--dependent endonuclease

G Floyd-Smith, E Slattery, and P Lengyel

One of the mediators of interferon action is a latent endoribonuclease (ribonuclease L) that is activated by (2'-5')oligoadenylates. Among the homopolymers of the four common ribonucleotides, activated ribonuclease L degrades at an appreciable rate only polyuridylic acid. In two natural RNA's tested the most frequent ribonuclease L cleavages occur after UA, UG, and UU (A, adenine; U, uracil; and G, guanine) and much less frequent cleavages after CA and AC (C, cytosine).


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