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Science 22 May 1981:
Vol. 212. no. 4497, pp. 937 - 938
DOI: 10.1126/science.7015504
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Articles

Science, Vol 212, Issue 4497, 937-938
Copyright © 1981 by American Association for the Advancement of Science

articles

Micromolar calcium stimulates proteolysis and glutamate binding in rat brain synaptic membranes

M Baudry, MC Bundman, EK Smith, and GS Lynch

Incubation of cortical synaptic membranes with low concentrations of calcium resulted in a decrease in the amount of a high-molecular-weight doublet protein and an increase in the sodium-independent binding of glutamate. Both effects were blocked by the thiol protease inhibitor leupeptin. These results suggest that calcium-induced proteolysis of membrane components regulates the number of glutamate receptors in neuronal membranes.


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