Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 22 May 1981:
Vol. 212. no. 4497, pp. 937 - 938
DOI: 10.1126/science.7015504
Prev | Table of Contents | Next

Articles

Science, Vol 212, Issue 4497, 937-938
Copyright © 1981 by American Association for the Advancement of Science

articles

Micromolar calcium stimulates proteolysis and glutamate binding in rat brain synaptic membranes

M Baudry, MC Bundman, EK Smith, and GS Lynch

Incubation of cortical synaptic membranes with low concentrations of calcium resulted in a decrease in the amount of a high-molecular-weight doublet protein and an increase in the sodium-independent binding of glutamate. Both effects were blocked by the thiol protease inhibitor leupeptin. These results suggest that calcium-induced proteolysis of membrane components regulates the number of glutamate receptors in neuronal membranes.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Axons break in animals lacking {beta}-spectrin.
M. Hammarlund, E. M. Jorgensen, and M. J. Bastiani (2007)
J. Cell Biol. 176, 269-275
   Abstract »    Full Text »    PDF »
The Calpain System.
D. E. GOLL, V. F. THOMPSON, H. LI, W. WEI, and J. CONG (2003)
Physiol Rev 83, 731-801
   Abstract »    Full Text »    PDF »
Retrograde perfusion with a sodium channel antagonist provides ischemic spinal cord protection.
J. J. Gangemi, J. A. Kern, S. D. Ross, K. S. Shockey, I. L. Kron, and C. G. Tribble (2000)
Ann. Thorac. Surg. 69, 1744-1748
   Abstract »    Full Text »    PDF »
Development of two types of calcium channels in cultured mammalian hippocampal neurons.
Y Yaari, B Hamon, and H. Lux (1987)
Science 235, 680-682
   Abstract »    PDF »
The biochemistry of memory: a new and specific hypothesis.
G Lynch and M Baudry (1984)
Science 224, 1057-1063
   Abstract »    PDF »
Entorhinal cortex lesions induce a decreased calcium transport in hippocampal mitochondria.
M Baudry, J Fuchs, M Kessler, D Arst, and G Lynch (1982)
Science 216, 411-413
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)