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Science 22 May 1981:
Vol. 212. no. 4497, pp. 933 - 935
DOI: 10.1126/science.7233187
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Articles

Science, Vol 212, Issue 4497, 933-935
Copyright © 1981 by American Association for the Advancement of Science

articles

Didemnins: antiviral and antitumor depsipeptides from a caribbean tunicate

KL Rinehart Jr, JB Gloer, RG Hughes Jr, HE Renis, JP McGovren, EB Swynenberg, DA Stringfellow, SL Kuentzel, and LH Li

Extracts of samples of a Caribbean tunicate (ascidian, sea squirt) of the family Didemnidae inhibit in vitro at low concentrations the growth of DNA and RNA viruses as well as L1210 leukemic cells. The active compounds isolated from the tunicate, didemnins A, B, and C, are depsipeptides, and didemnin B (a derivative of didemnin A) is the component active at the lowest concentration in inhibiting viral replication in vitro and P388 leukemia in vivo.


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