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Science 22 May 1981:
Vol. 212. no. 4497, pp. 929 - 930
DOI: 10.1126/science.6262911
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Articles

Science, Vol 212, Issue 4497, 929-930
Copyright © 1981 by American Association for the Advancement of Science

articles

Transmitter sensitivity of neurons assayed by autoradiography

D Yoshikami

Ionic conductance channels that are opened by activating nicotinic acetylcholine receptors at synapses of sympathetic neurons are permeable to small organic amines. Uptake of a tritium-labeled amine through these channels can be measured by autoradiography. This provides a simple and direct way to assess the sensitivity of individual neurons to acetylcholine without using microelectrodes.


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