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Science 22 May 1981:
Vol. 212. no. 4497, pp. 923 - 924
DOI: 10.1126/science.7195067
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Articles

Science, Vol 212, Issue 4497, 923-924
Copyright © 1981 by American Association for the Advancement of Science

articles

Tumor shedding and coagulation

HF Dvorak, SC Quay, NS Orenstein, AM Dvorak, P Hahn, AM Bitzer, and AC Carvalho

Three syngeneic carcinomas from two species shed plasma membrane vesicles when cultured in vitro or grown in the ascites tumor form in vivo. Shed vesicles carry procoagulant activity that can account for the activation of the clotting system and the fibrin deposition associated with these and many other types of malignancy in animals and man.


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