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Science 22 May 1981:
Vol. 212. no. 4497, pp. 921 - 923
DOI: 10.1126/science.7233185
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Articles

Science, Vol 212, Issue 4497, 921-923
Copyright © 1981 by American Association for the Advancement of Science

articles

Membrane fusion through point defects in bilayers

SW Hui, TP Stewart, LT Boni, and PL Yeagle

Fusion between bilayers of mixed egg phosphatidylcholine and soybean phosphatidylethanolamine was induced by freezing and thawing. Contact points between bilayers were observed by freeze fracture electron microscopy, and isotropic molecular motional averaging was detected by phosphorus-31 nuclear magnetic resonance under fusion conditions. A molecular model of point defect structure is proposed as an intermediate stage of fusion.


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