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Science 22 May 1981:
Vol. 212. no. 4497, pp. 919 - 920
DOI: 10.1126/science.7233184
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Articles

Science, Vol 212, Issue 4497, 919-920
Copyright © 1981 by American Association for the Advancement of Science

articles

Cystinuria in the maned wolf of South America

KC Bovee, M Bush, J Dietz, P Jezyk, and S Segal

Of 42 maned wolves in zoos or live-trapped in Brazil, 34 had excessive cystine in their urine. Renal clearance studies of five of the affected wolves revealed a variable defect for the reabsorption of cystine and dibasic amino acids. The renal tubular handling of other solutes including glucose, phosphate, sodium, potassium, and uric acid was considered normal. Urinary calculi composed of cystine were found in four wolves and proved fatal in three of them. With the exception of the high incidence in this species, this hereditary disease resembles the disorder described in dogs and humans.


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Slc7a9-deficient mice develop cystinuria non-I and cystine urolithiasis.
L. Feliubadalo, M. L. Arbones, S. Manas, J. Chillaron, J. Visa, M. Rodes, F. Rousaud, A. Zorzano, M. Palacin, and V. Nunes (2003)
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