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Science 22 May 1981:
Vol. 212. no. 4497, pp. 888 - 893
DOI: 10.1126/science.7233180
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Articles

Science, Vol 212, Issue 4497, 888-893
Copyright © 1981 by American Association for the Advancement of Science

articles

The mutation component of genetic damage

JF Crow and C Denniston

The mutation component, M, is a measure of the proportion of the impact of a genetic condition that is attributable to recurrent mutation. For a trait maintained by balance between mutation and directional selection, M is approximately the broad-sense heritability; for a measured character where the mean and optimum coincide, M is about half the heritability. If the narrow-sense heritability is high, the impact changes relatively rapidly with a change in mutation rate. If the narrow-sense heritability is low, M cannot be predicted, but the change in impact following a change in mutation rate, if any, is very slow.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Base Excision Repair Is Limited by Different Proteins in Male Germ Cell Nuclear Extracts Prepared from Young and Old Mice.
G. W. Intano, C. A. McMahan, J. R. McCarrey, R. B. Walter, A. E. McKenna, Y. Matsumoto, M. A. MacInnes, D. J. Chen, and C. A. Walter (2002)
Mol. Cell. Biol. 22, 2410-2418
   Abstract »    Full Text »    PDF »
Mutation frequency declines during spermatogenesis in young mice but increases in old mice.
C. A. Walter, G. W. Intano, J. R. McCarrey, C. A. McMahan, and R. B. Walter (1998)
PNAS 95, 10015-10019
   Abstract »    Full Text »    PDF »


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