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Science 15 May 1981:
Vol. 212. no. 4496, pp. 827 - 829
DOI: 10.1126/science.7221567
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Articles

Science, Vol 212, Issue 4496, 827-829
Copyright © 1981 by American Association for the Advancement of Science

articles

Two distinct central serotonin receptors with different physiological functions

SJ Peroutka, RM Lebovitz, and SH Snyder

Two distinct serotonin (5-hydroxytryptamine) receptors designated serotonin 1 and serotonin 2 bind tritium-labeled serotonin and tritium-labeled spiroperidol, respectively. Drug potencies at serotonin 2 sites, but not at serotonin 1 sites, predict their effects on the "serotonin behavioral syndrome," indicating that serotonin 2 sites mediate these behaviors. The limited correlation of drug effects with regulation by guanine nucleotides suggests that serotonin 1 sites might be linked to adenylate cyclase. Drug specificities of serotonin-elicited synaptic inhibition and excitation may reflect serotonin 1 and serotonin 2 receptor interactions, respectively.


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