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Science 15 May 1981:
Vol. 212. no. 4496, pp. 817 - 818
DOI: 10.1126/science.7221564
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Articles

Science, Vol 212, Issue 4496, 817-818
Copyright © 1981 by American Association for the Advancement of Science

articles

Feminizing effect of mesonephros on cultured differentiating mouse gonads and ducts

AG Byskov and J Grinsted

Gonads were removed from fetal mice at about the time that gonadal sex differentiation occurs. The gonads were cultured in vitro with or without their mesonephric tissue. When gonads and ducts removed from sexually undifferentiated fetuses were cultured together, the gonads of both sexes developed female characteristics, whereas gonads cultured without mesonephros developed according to the sex of the fetus from which they were removed. Gonads of sexually differentiated fetuses developed whether they were cultured with or without the mesonephros.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Number of germ cells and somatic cells in human fetal testes during the first weeks after sex differentiation.
E. Bendsen, A. G. Byskov, S. B. Laursen, H.-P. E. Larsen, C. Y. Andersen, and L. G. Westergaard (2003)
Hum. Reprod. 18, 13-18
   Abstract »    Full Text »    PDF »
Estrogen-Induced Gonadal Sex Reversal in the Tammar Wallaby.
D. Coveney, G. Shaw, and M. B. Renfree (2001)
Biol Reprod 65, 613-621
   Abstract »    Full Text »    PDF »
The Differential Fate of Mesonephric Tubular-Derived Efferent Ductules in Estrogen Receptor-{alpha} Knockout Versus Wild-Type Female Mice.
C. S. Rosenfeld, P. S. Cooke, T. H. Welsh Jr., G. Simmer, M. G. Hufford, J.-A. Gustafsson, R. A. Hess, and D. B. Lubahn (2000)
Endocrinology 141, 3792-3798
   Abstract »    Full Text »    PDF »
Mesonephric contribution to testis differentiation in the fetal mouse.
M. Buehr, S. Gu, and A. McLaren (1993)
Development 117, 273-281
   Abstract »    PDF »


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