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Science 15 May 1981:
Vol. 212. no. 4496, pp. 815 - 816
DOI: 10.1126/science.7221563
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Articles

Science, Vol 212, Issue 4496, 815-816
Copyright © 1981 by American Association for the Advancement of Science

articles

The prolactin gene is located on chromosome 6 in humans

D Owerbach, WJ Rutter, NE Cooke, JA Martial, and TB Shows

The gene for prolactin has been located on chromosome 6 in humans. DNA fragments of 4.8 and 4.0 kilobases containing prolactin gene sequences were identified in human genomic DNA, whereas DNA fragments of 7.4, 3.6, and 3.3 kilobases containing prolactin gene sequences were found in mouse cells. In somatic cell hybrids of human and mouse cells the 7.4-, 3.6-, and 3.3-kilobase mouse fragments were always present, whereas the 4.8- and 4.0-kilobase human fragments were only present when human chromosome 6 was also present. We conclude that the prolactin gene resides on chromosome 6, a different location from those of the genes for the related hormones chorionic somatomammotropin and growth hormone.


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Tumor Necrosis Factor-{alpha} Activates the Human Prolactin Gene Promoter via Nuclear Factor-{kappa}B Signaling.
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Prolactin: Structure, Function, and Regulation of Secretion.
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Ann Intern Med 105, 238-253
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Somatic cell genetics and gene families.
P D'Eustachio and F. Ruddle (1983)
Science 220, 919-924
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