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Science 8 May 1981:
Vol. 212. no. 4495, pp. 687 - 689
DOI: 10.1126/science.7221559
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Articles

Science, Vol 212, Issue 4495, 687-689
Copyright © 1981 by American Association for the Advancement of Science

articles

Cholecystokinin antibody injected in cerebral ventricles stimulates feeding in sheep

MA Della-Fera, CA Baile, BS Schneider, and JA Grinker

The role of brain cholecystokinin peptides in satiety was further assessed by using antibody to cholecystokinin to reduce cholecystokinin activity in the cerebrospinal fluid of sheep. Food intakes were increased approximately 100 percent during the 2-hour continuous injection of antibody into the cerebrospinal fluid. This supports the hypothesis that, during feeding, cholecystokinin is released into the cerebrospinal fluid, which transports it to the receptors that elicit satiety.


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