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Science 8 May 1981:
Vol. 212. no. 4495, pp. 672 - 675
DOI: 10.1126/science.7221554
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Articles

Science, Vol 212, Issue 4495, 672-675
Copyright © 1981 by American Association for the Advancement of Science

articles

Measles virus nucleotide sequences: detection by hybridization in situ

AT Haase, P Ventura, CJ Gibbs Jr, and WW Tourtellotte

A tritium-labeled probe that detects measles virus nucleotide sequences was hybridized in situ to cells infected with measles virus and to sections of brain tissue from patients with subacute sclerosing panencephalitis and from patients with multiple sclerosis. The measles virus genome was detected in many cells in subacute sclerosing panencephalitis where this virus would have been missed by methods such as immunofluorescence. Measles virus sequences were also found in two foci in one of four cases of multiple sclerosis. This refined method of hybridization in situ, which can be useful in the search for covert virus infections of man, provides evidence that viruses may be involved in multiple sclerosis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Multiple Sclerosis.
G. W. ELLISON, B. R. VISSCHER, M. C. GRAVES, and J. L. FAHEY (1984)
Ann Intern Med 101, 514-526
   Abstract »    PDF »
Biotinated probe containing a long-terminal repeat hybridized to a mouse colon tumor and normal tissue.
M. Royston and L. Augenlicht (1983)
Science 222, 1339-1341
   Abstract »    PDF »
Rapid evolution of RNA genomes.
J Holland, K Spindler, F Horodyski, E Grabau, S Nichol, and S VandePol (1982)
Science 215, 1577-1585
   Abstract »    PDF »


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