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Science 24 April 1981:
Vol. 212. no. 4493, pp. 452 - 455
DOI: 10.1126/science.6259735
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Articles

Science, Vol 212, Issue 4493, 452-455
Copyright © 1981 by American Association for the Advancement of Science

articles

Epstein-Barr viral DNA: infectivity for human placental cells

G Miller, E Grogan, L Heston, J Robinson, and D Smith

Purified DNA of Epstein-Barr virus (EBV) is regularly infectious by means of the "calcium" method of transfection. Cultured human placental cells exposed to EBV DNA of two transforming strains, FF41 and B95, produce virus that is capable of converting normal B lymphocytes into established cell lines. After treatment with EBV (FF41) DNA and EBV (HR-1) DNA the placental cells display antigens associated with the productive viral cycle. The placental cells have not developed foci or other signs of morphologic transformation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cell Fusion by Nasopharyngeal Carcinoma-Derived Epstein-Barr Virus.
T. Takimoto, H. Sato, H. Ogura, and T. Miyazaki (1987)
Arch Otolaryngol Head Neck Surg 113, 510-513
   Abstract »    PDF »
Latent Herpesviruses of Humans.
M. C. JORDAN, G. W. JORDAN, J. G. STEVENS, and G. MILLER (1984)
Ann Intern Med 100, 866-880
   Abstract »    PDF »
Infection of normal human epithelial cells by Epstein-Barr virus.
I. Shapiro and D. Volsky (1983)
Science 219, 1225-1228
   Abstract »    PDF »


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